Egypt protests: Many at Cairo 'day of departure' rally
The tens of thousands of protesters attending the "day of departure" rally in Tahrir Square waved flags and chanted "Leave! Leave! Leave!"
Soldiers have been guarding the area to limit disruption by Mubarak supporters.
Mr Mubarak has said he is "fed up" with being in power, but that he is does not want to resign as it will cause chaos.
Meanwhile, speaking in Washington, US President Barack Obama called for an "orderly transition that begins right now" in Egypt.
Mr Obama said the "entire world is watching" and urged Mr Mubarak to "make the right decision".
'Chaos'
Mr Mubarak told ABC News on Thursday that the banned Islamist opposition group, the Muslim Brotherhood, would fill a power vacuum left by his absence.
He also denied that his administration was behind the violence of recent days, and that his son Gamal intended to run for president.
Opposition leader Mohamed ElBaradei took issue with the president's remarks, saying: "We as a people are fed up as well, it is not only him."
"The idea that there would be chaos is symptomatic of a dictatorship. He thinks if he leaves power the whole country will fall apart."
And White House spokesman Robert Gibbs also rejected the argument that there might be chaos if Mr Mubarak stepped down now.
"There are concrete actions that he can take... towards moving down the path of real change that can lessen instability and can ensure that we do not descend into the chaos that he describes," he told reporters.
"The government, the president and the vice-president need to sit down with a coalition that constitutes a broad cross-section of Egyptian society... Until that happens, my guess is that the people you see on TV aren't going anywhere," he added.
A senior member of the Muslim Brotherhood, Issam al-Aryan, meanwhile denied that his group had eyes on the presidency, telling the BBC that it would prefer the opposition to nominate a consensus candidate.
"We want a civil state, based on Islamic principles. A democratic state, with a parliamentary system, with freedom to form parties, press freedom, and an independent and fair judiciary," he added.
Soldiers have been guarding the area to limit disruption by Mubarak supporters.
Mr Mubarak has said he is "fed up" with being in power, but that he is does not want to resign as it will cause chaos.
Meanwhile, speaking in Washington, US President Barack Obama called for an "orderly transition that begins right now" in Egypt.
Mr Obama said the "entire world is watching" and urged Mr Mubarak to "make the right decision".
'Chaos'
Mr Mubarak told ABC News on Thursday that the banned Islamist opposition group, the Muslim Brotherhood, would fill a power vacuum left by his absence.
He also denied that his administration was behind the violence of recent days, and that his son Gamal intended to run for president.
"The idea that there would be chaos is symptomatic of a dictatorship. He thinks if he leaves power the whole country will fall apart."
And White House spokesman Robert Gibbs also rejected the argument that there might be chaos if Mr Mubarak stepped down now.
"There are concrete actions that he can take... towards moving down the path of real change that can lessen instability and can ensure that we do not descend into the chaos that he describes," he told reporters.
"The government, the president and the vice-president need to sit down with a coalition that constitutes a broad cross-section of Egyptian society... Until that happens, my guess is that the people you see on TV aren't going anywhere," he added.
A senior member of the Muslim Brotherhood, Issam al-Aryan, meanwhile denied that his group had eyes on the presidency, telling the BBC that it would prefer the opposition to nominate a consensus candidate.
"We want a civil state, based on Islamic principles. A democratic state, with a parliamentary system, with freedom to form parties, press freedom, and an independent and fair judiciary," he added.
